<scp>LncRNA HOX transcript antisense RNA</scp> mediates hyperglycemic‐induced injury in the renal tubular epithelial cell via the <scp>miR‐126‐5pAkt</scp> axis

Abstract Objective: To investigate the involvement of HOX transcript antisense RNA (HOTAIR) in injury renal tubular epithelial cells induced by high glucose. Results: In glucose‐induced HK‐2 cells, expression HOTAIR was upregulated, resulting suppressed cell proliferation. Meanwhile, upregulates pro‐apoptotic proteins Bax and cleaved caspase‐3, while downregulating anti‐apoptotic protein Bcl‐2. Luciferase reporter assays revealed that could target miR‐126‐5p. Additionally, it found PI3K/Akt signaling pathway serves as a downstream Knockdown relieved apoptosis, whereas further inhibition miR‐126‐5p led to apoptosis cells. Conclusions: plays regulatory role mediating injuries specifically affecting viability, via miR‐126‐5p/PI3K/Akt pathway.